MULTIPLE ENDOCRINE NEOPLASIA SYNDROMES

INTRODUCTION: – multiple endocrine neoplasia (MEN):- it is a group of inherited disorder which mainly affects the endocrine system. Endocrine system regulates many hormones in the body.

TYPES AND CAUSES OF MULTIPLE ENDOCRINE NEOPLASIA SYNDROMES: –

there are many types of MEN that cause this syndromes:-

MEN Type 1:- it is due to mutation in MEN1 gene. Parathyroid glands, pancreas and pituitary gland affects from mutation in MEN 1.

MEN Type 2A:- it is due to RET proto- oncogene. Thyroid gland, adrenal glands, parathyroid glands affects from this.

MEN Type 2B:- it is due to RET- oncogene. 

SYMPTOMS: – symptoms depends on the type of MEN:-

1. MEN 1:- 

• Tumors in parathyroid gland.
• Hyperparathyroidism.
• Hyperkalemia.
• Insulinomas.
• Gastrinomas.
• Glucagonomas.
• Tumor in pituitary gland.

2. MEN 2A:- 

• Medullary thyroid carcinoma.
• Tumor in adrenal gland.
• Hyperparathyroidism.
• Hyperkalemia.

3. MEN 2B:- 

• MTC.
• Pheochromocytoma.
• Ganglioneuromatos.
• Long limbs, joint hypermobility.

OTHER COMMON SYMPTOMS ARE:- 

1. Weight loss.
2. Mood changes.
3. Energy level down.
4. Lump or mass feels on affected area.
5. Abdominal pain.
6. Diarrhea, vomiting.
7. Constipation.
8. Joint pain.
9. Long limbs.
10. HTN.
11. Loss of appetite.
12. Weakness etc.

INVESTIGATIONS:- 

1. Genetic testing.
2. CBC.
3. Hormone level assessment.
4. Ultrasound.
5. CT- scans.
6. MRI
7. Octreotide scan.
8. Biopsy.

MULTIPLE ENDOCRINE NEOPLASIA SYNDROMES HOMOEOPATHIC TREATMENT:-

PHOSPHORUS:- 

1. It is indicated medicine in MEN.
2. Person is debilitated.
3. Loose and offensive stools with complete exhaustion thereafter.
4. Palpitation of heart.
5. Shortness of breath or dyspnea on least exertion.
6. Loss of appetite.

ARSENIC ALBUM:-

1. Dyspnea, shortness of breath and pallor.
2. Profound blood changes.
3. Heart action is weak.
4. Glandular enlargement.
5. -patient is very restless and anxious.
6. Aggravation in midnight and afternoon.

SILICEA:-

1. Icy cold and sweaty feet.
2. Silicea can stimulate the organisms to reabsorb fibrotic conditions and scar tissue.
3. Disease of bone, caries, necrosis and tumor.
4. Ill effects of vaccinations.
5. Supportive process.